| Termin | Heim | Gast | Ergebnis |
|---|---|---|---|
| 12.11.22 16:00 | UD Barbadas | Real Valladolid | 0:2 |
| 12.11.22 16:00 | CD Fuentes | CA Osasuna | 1:4 |
| 12.11.22 16:00 | CD Manacor | Andorra CF | 1:3 |
| 12.11.22 17:00 | CD Guijuelo | Deportivo La Coruna | 2:0 |
| 12.11.22 17:00 | CD Artistico Navalcarnero | UD Logrones | 1:3n.V. |
| 12.11.22 17:00 | Olot | UD Levante | 0:4 |
| 12.11.22 17:00 | Atletico Saguntino | SD Amorebieta | 1:0n.V. |
| 12.11.22 18:00 | CD Guadalajara | SD Ponferradina | 2:1 |
| 12.11.22 18:00 | Sestao River Club | Racing de Ferrol | 1:0 |
| 12.11.22 18:00 | Beasain | Sporting Gijon | 2:3n.V. |
| 12.11.22 18:00 | Utrera | AD Ceuta FC | 0:1 |
| 12.11.22 18:00 | SD Gernika Club | CD Leganes | 6:5n.E. |
| 12.11.22 18:00 | Racing Rioja | Gimnastica Segoviana | 0:2 |
| 12.11.22 18:00 | Huetor Tajar | Albacete Balompie | 0:3n.V. |
| 12.11.22 18:00 | Arenas Club de Getxo | CD Lugo | 1:0 |
| 12.11.22 18:30 | CD Autol | RCD Mallorca | 0:6 |
| 12.11.22 18:30 | CD L'Alcora | FC Elche | 0:3 |
| 12.11.22 20:00 | CD Coria | CF Fuenlabrada | 2:0 |
| 12.11.22 20:00 | CF Cristo Atletico | UD Ibiza Eivissa | 0:2n.V. |
| 12.11.22 20:00 | CP Cacereno | Cordoba CF | 3:0 |
| 12.11.22 21:00 | CD Rincon | Espanyol Barcelona | 0:3 |
| 12.11.22 21:00 | Santa Amalia | FC Villarreal | 0:9 |
| 12.11.22 22:00 | SD Almazan | Atletico Madrid | 0:2 |
| 13.11.22 12:00 | CD Lealtad de Villaviciosa | CD Teneriffa | 0:2 |
| 13.11.22 12:00 | CD Diocesano | Real Saragossa | 1:0 |
| 13.11.22 12:00 | Gimnastica de Torrelavega | Real Oviedo | 2:3n.V. |
| 13.11.22 12:00 | CD Alfaro | FC Cartagena | 0:1 |
| 13.11.22 12:00 | CD Ibiza Islas Pitiusas | CF Rayo Majadahonda | 3:1 |
| 13.11.22 12:00 | CE Manresa | CF Pontevedra | 1:3 |
| 13.11.22 12:00 | CF Hercules | CF La Nucia | 2:4n.V. |
| 13.11.22 12:00 | Arnedo | Atletico Baleares | 5:4n.E. |
| 13.11.22 12:00 | CFJ Mollerussa | Rayo Vallecano | 1:3 |
| 13.11.22 12:00 | CD Atletico Paso | Real Murcia | 4:3n.E. |
| 13.11.22 12:00 | CD Quintanar del Rey | FC Girona | 1:2n.V. |
| 13.11.22 12:00 | Vimenor CF | CD Mirandes | 0:2 |
| 13.11.22 12:00 | Las Rozas CF | SD Eibar | 0:3 |
| 13.11.22 12:00 | Recreativo Huelva | Burgos CF | 3:4n.E. |
| 13.11.22 12:00 | Deportiva Santa Eulalia del Rio | FC Malaga | 8:9n.E. |
| 13.11.22 12:00 | AD Union Adarve | Linares Deportivo | 1:2 |
| 13.11.22 12:00 | Juventud Torremolinos CF | SD Huesca | 6:4n.E. |
| 13.11.22 16:00 | CD Algar | Celta Vigo | 1:6 |
| 13.11.22 16:00 | CA Cirbonero | CF Intercity | 0:1 |
| 13.11.22 16:00 | Velarde Camargo | FC Sevilla | 0:2 |
| 13.11.22 16:30 | CD Teruel | UD Las Palmas | 0:1 |
| 13.11.22 17:00 | CF Ourense | AD Alcorcon | 3:5n.E. |
| 13.11.22 17:00 | FC Coruxo | Eldense | 4:6n.E. |
| 13.11.22 17:00 | Yeclano Deportivo | FC Granada | 2:3 |
| 13.11.22 17:00 | AD San Juan | CD Numancia | 0:2 |
| 13.11.22 18:00 | Utebo | Merida AD | 5:6n.E. |
| 13.11.22 18:00 | Club Lleida Esportiu | Deportivo Alaves | 0:1 |
| 13.11.22 18:30 | CD San Roque de Lepe | FC Getafe | 2:3n.V. |
| 13.11.22 18:30 | Real Union Club | FC Cadiz | 3:2 |
| 13.11.22 19:00 | CD Cazalegas | Real Sociedad | 1:4 |
| 13.11.22 21:00 | CD Arenteiro | UD Almeria | 2:0 |
| 13.11.22 21:00 | Alzira | Athletic Bilbao | 0:2 |